This is a descriptive, non-interventional study that includes systematic reviews and disease and health modelling, aiming to obtain accurate estimates of the disease health and economic burden. The study complies with the health estimated reporting guidelines (GATHER). The following steps will be followed:1.Review of the literature on the prevalence, the number of deaths and the mortality rates attributable to CD and CCC in endemic and non-endemic countries.2.Estimation of the prevalence, the number of deaths and the mortality rates attributable to CD and CCC in endemic and non-endemic countries, including correction for subnotification, to allow the calculation of quantitative population-level health estimates of health indicators, including indicators of health status: cause-specific numbers of deaths, mortality, and prevalence of the disease.3.Estimation of the global and country-specific health burden, in terms of DALYs (disability-adjusted life-years), attributable to chronic Chagas disease and its sequelae.4.Estimation of the global and country-specific economic burden of chronic Chagas disease and its sequelae, from the societal perspective.5.To perform subanalysis on the health and economic burden of the disease focusing on specific analysis on one side for oral transmitted cases and on the other side on those that need heart transplantation and use of electrical cardiac devices, like pacemakers and cardiac defibrillators independent of way of transmission.
